[HTML][HTML] Blood pressure is regulated by an α1D-adrenergic receptor/dystrophin signalosome
JS Lyssand, MC DeFino, X Tang, AL Hertz… - Journal of biological …, 2008 - ASBMB
Hypertension is a cardiovascular disease associated with increased plasma
catecholamines, overactivation of the sympathetic nervous system, and increased vascular
tone and total peripheral resistance. A key regulator of sympathetic nervous system function
is the α 1D-adrenergic receptor (AR), which belongs to the adrenergic family of G-protein-
coupled receptors (GPCRs). Endogenous catecholamines norepinephrine and epinephrine
activate α 1D-ARs on vascular smooth muscle to stimulate vasoconstriction, which increases …
catecholamines, overactivation of the sympathetic nervous system, and increased vascular
tone and total peripheral resistance. A key regulator of sympathetic nervous system function
is the α 1D-adrenergic receptor (AR), which belongs to the adrenergic family of G-protein-
coupled receptors (GPCRs). Endogenous catecholamines norepinephrine and epinephrine
activate α 1D-ARs on vascular smooth muscle to stimulate vasoconstriction, which increases …