Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice
DL Hogan, DL Crombie, JI Isenberg… - …, 1997 - gastrojournal.org
BACKGROUND & AIMS: Duodenal bicarbonate secretion is an important factor in epithelial
protection. The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in
acid-induced bicarbonate secretion is unknown. The aim of this study was to determine
whether CFTR mediates acid-stimulated duodenal epithelial bicarbonate secretion.
METHODS: Basal and stimulated bicarbonate secretion was examined in the cystic fibrosis
murine model cftrm1UNC, which displays defective CFTR in various organs including …
protection. The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in
acid-induced bicarbonate secretion is unknown. The aim of this study was to determine
whether CFTR mediates acid-stimulated duodenal epithelial bicarbonate secretion.
METHODS: Basal and stimulated bicarbonate secretion was examined in the cystic fibrosis
murine model cftrm1UNC, which displays defective CFTR in various organs including …