CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma

VV Jain, K Kitagaki, T Businga, I Hussain… - Journal of Allergy and …, 2002 - Elsevier
Background: We have previously demonstrated that CpG oligodeoxynucleotides (CpG-
ODNs) protect against eosinophilia and airway hyperresponsiveness in murine models of
allergen-induced asthma. Acute inflammation is hypothesized to induce chronic airway
responses, but no previous studies have evaluated the effects of CpG-ODNs on allergen-
induced airway remodeling. Because remodeling is thought to be responsible for many of
the long-term adverse effects on asthmatic patients, we evaluated whether CpG-ODNs might …