Calcium-activated nonselective cation channels in mammalian cardiomyocytes
R Guinamard, M Demion, A Chatelier, P Bois - Trends in cardiovascular …, 2006 - Elsevier
A number of calcium-activated nonselective cation (NSCCa) currents recorded from cardiac
preparations have been described in the literature. These currents are implicated in
membrane depolarization and in the modulation of cardiac activity. The discovery of a novel
family of cation channels, the “transient receptor potential”(TRP) protein family, has revived
interest in the study of nonselective cation channels. In particular, the TRPM4 protein
provides the basis for an NSCCa channel detected in heart preparations. The role of this …
preparations have been described in the literature. These currents are implicated in
membrane depolarization and in the modulation of cardiac activity. The discovery of a novel
family of cation channels, the “transient receptor potential”(TRP) protein family, has revived
interest in the study of nonselective cation channels. In particular, the TRPM4 protein
provides the basis for an NSCCa channel detected in heart preparations. The role of this …