[HTML][HTML] The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
J Weidenfeld, W Shu, L Zhang, SE Millar… - Journal of Biological …, 2002 - ASBMB
In this study, we find that WNT7b is the only member of the WNT family of
autocrine/paracrine signaling molecules whose expression in the lung is restricted to the
airway epithelium during embryonic development. To study the transcriptional mechanisms
that underlie this restricted pattern of WNT7b expression, we isolated the proximal 1.0-kb
mouse WNT7b promoter and mapped the transcriptional start sites. Transfection of the lung
epithelial cell line MLE-15, which expresses WNT7b, shows that the 1.0-kb mouse WNT7b …
autocrine/paracrine signaling molecules whose expression in the lung is restricted to the
airway epithelium during embryonic development. To study the transcriptional mechanisms
that underlie this restricted pattern of WNT7b expression, we isolated the proximal 1.0-kb
mouse WNT7b promoter and mapped the transcriptional start sites. Transfection of the lung
epithelial cell line MLE-15, which expresses WNT7b, shows that the 1.0-kb mouse WNT7b …