Increased expression of platelet-derived growth factor receptor-β in airway fibroblasts of severe asthmatics
CC Lewis, HW Chu, JY Westcott, ER Sutherland… - Chest, 2003 - journal.chestnet.org
The subepithelial thickening of asthmatic airways is manifested by increased fibroblast/
myofibroblast proliferation and deposition of extracellular matrix proteins including collagen.
This feature of asthma can be modeled in mice that are sensitized and challenged with
ovalbumin, but quantitation has been suboptimal. In this study, we describe the development
of a quantitation method using computerized image analysis. Mice (SV129/C57BL/6) were
sensitized by intraperitoneal injection of 10 g of ovalbumin in 0.1 mL of saline solution on …
myofibroblast proliferation and deposition of extracellular matrix proteins including collagen.
This feature of asthma can be modeled in mice that are sensitized and challenged with
ovalbumin, but quantitation has been suboptimal. In this study, we describe the development
of a quantitation method using computerized image analysis. Mice (SV129/C57BL/6) were
sensitized by intraperitoneal injection of 10 g of ovalbumin in 0.1 mL of saline solution on …