Mitotic checkpoints: from yeast to cancer
K Wassmann, R Benezra - Current opinion in genetics & development, 2001 - Elsevier
K Wassmann, R Benezra
Current opinion in genetics & development, 2001•ElsevierSeparation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-
cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular
mechanisms controlling this checkpoint have been identified. In addition, loss of this
checkpoint has been shown to result in chromosome missegregation in higher eukaryotes
and may contribute to the genomic instability observed in human cancers.
cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular
mechanisms controlling this checkpoint have been identified. In addition, loss of this
checkpoint has been shown to result in chromosome missegregation in higher eukaryotes
and may contribute to the genomic instability observed in human cancers.
Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.
Elsevier
