Leptin receptor action and mechanisms of leptin resistance
H Münzberg, M Björnholm, SH Bates… - Cellular and Molecular …, 2005 - Springer
H Münzberg, M Björnholm, SH Bates, MG Myers
Cellular and Molecular Life Sciences, 2005•SpringerThe adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine
function. Resistance to the appetite-suppressing effects of leptin is associated with common
forms of obesity. Here, we review the mechanisms by which leptin activates intracellular
signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss
potential mechanisms of leptin resistance, specifically focusing on data regarding the
neuroanatomical locus of leptin resistance and potential mechanisms by which expression …
function. Resistance to the appetite-suppressing effects of leptin is associated with common
forms of obesity. Here, we review the mechanisms by which leptin activates intracellular
signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss
potential mechanisms of leptin resistance, specifically focusing on data regarding the
neuroanatomical locus of leptin resistance and potential mechanisms by which expression …
Abstract
The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss potential mechanisms of leptin resistance, specifically focusing on data regarding the neuroanatomical locus of leptin resistance and potential mechanisms by which expression of the suppressor of cytokine signaling-3 may impair leptin action.
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