FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834
K McLean, S Schirm, A Johns, J Morser, DR Light - Thrombosis research, 2001 - Elsevier
During thrombosis, vascular wall cells are exposed to clotting factors, including the
procoagulant proteases thrombin and factor Xa (FXa), both known to induce cell signaling.
FXa shows dose-dependent induction of intracellular Ca2+ transients in vascular wall cells
that is active-site-dependent, Gla-domain-independent, and enhanced by FXa assembly into
the prothrombinase complex. FXa signaling is independent of prothrombin activation as
shown by the lack of inhibition by argatroban, hirudin and the sulfated C-terminal peptide of …
procoagulant proteases thrombin and factor Xa (FXa), both known to induce cell signaling.
FXa shows dose-dependent induction of intracellular Ca2+ transients in vascular wall cells
that is active-site-dependent, Gla-domain-independent, and enhanced by FXa assembly into
the prothrombinase complex. FXa signaling is independent of prothrombin activation as
shown by the lack of inhibition by argatroban, hirudin and the sulfated C-terminal peptide of …