Background On the basis of observations in rodents, leptin is thought to play a key role in the
regulation of energy expenditure and food intake, but less is known of its influence on
ingestive behavior and energy balance in humans. Objective We examined the effect in
women of a chronic energy deficit on plasma leptin concentrations and self-reported
appetite and explored possible relations between leptin and appetite sensations. Design
Twelve healthy women (body mass index, in kg/m 2: 23–37) participated in a metabolic ward …