Prolonged shedding of amantadine-resistant influenza A viruses by immunodeficient patients: detection by polymerase chain reaction-restriction analysis
AI Klimov, E Rocha, FG Hayden… - Journal of Infectious …, 1995 - academic.oup.com
AI Klimov, E Rocha, FG Hayden, PA Shult, LF Roumillat, NJ Cox
Journal of Infectious Diseases, 1995•academic.oup.comAbstract Consecutive A (H3N2) influenza virus isolates from 2 influenza virus-infected
immunodeficient patients treated with amantadine were examined using a novel polymerase
chain reaction (PCR) restriction analysis for resistance to this antiviral compound. The data
indicate that immunodeficient patients may shed resistant viruses for prolonged periods and
with different drug resistance mutations present at different times. This PCR-restriction
technique allows rapid detection of amantadine-or rimantadine-resistant strains.
immunodeficient patients treated with amantadine were examined using a novel polymerase
chain reaction (PCR) restriction analysis for resistance to this antiviral compound. The data
indicate that immunodeficient patients may shed resistant viruses for prolonged periods and
with different drug resistance mutations present at different times. This PCR-restriction
technique allows rapid detection of amantadine-or rimantadine-resistant strains.
Abstract
Consecutive A (H3N2) influenza virus isolates from 2 influenza virus-infected immunodeficient patients treated with amantadine were examined using a novel polymerase chain reaction (PCR)restriction analysis for resistance to this antiviral compound. The data indicate that immunodeficient patients may shed resistant viruses for prolonged periods and with different drug resistance mutations present at different times. This PCR-restriction technique allows rapid detection of amantadine- or rimantadine-resistant strains.
Oxford University Press