Subtype C is associated with increased vaginal shedding of HIV-1
GC John-Stewart, RW Nduati… - The Journal of …, 2005 - academic.oup.com
The Journal of infectious diseases, 2005•academic.oup.com
The prevalence of human immunodeficiency virus (HIV)–1–infected cells and HIV-1 RNA
levels in genital secretions and breast milk and the risk of mother-to-child transmission of
HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women
infected with subtype C were significantly more likely to shed HIV-1–infected vaginal cells
than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval
{CI}, 1.4–8.8]; P=. 006). This relationship held after adjusting for age, CD4 cell count, and …
levels in genital secretions and breast milk and the risk of mother-to-child transmission of
HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women
infected with subtype C were significantly more likely to shed HIV-1–infected vaginal cells
than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval
{CI}, 1.4–8.8]; P=. 006). This relationship held after adjusting for age, CD4 cell count, and …
Abstract
The prevalence of human immunodeficiency virus (HIV)–1–infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1–infected vaginal cells than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval {CI}, 1.4–8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1–8.6]; P=.03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1
Oxford University Press