Development of a Mouse Model of Helicobacter pylori Infection that Mimics Human Disease
M Marchetti, B Arico, D Burroni, N Figura, R Rappuoli… - Science, 1995 - science.org
M Marchetti, B Arico, D Burroni, N Figura, R Rappuoli, P Ghiara
Science, 1995•science.orgThe human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease,
and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting
fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology
resembling human disease was observed in infections with cytotoxin-producing strains but
not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected
mice from bacterial infection. This mouse model will allow the development of therapeutic …
and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting
fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology
resembling human disease was observed in infections with cytotoxin-producing strains but
not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected
mice from bacterial infection. This mouse model will allow the development of therapeutic …
The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology resembling human disease was observed in infections with cytotoxin-producing strains but not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected mice from bacterial infection. This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans.
AAAS