[HTML][HTML] Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the
bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes
phosphorylated on tyrosine residues and initiates cytoskeletal rearrangements. We
demonstrate here that Src-like protein-tyrosine kinases mediate CagA phosphorylation in
vitro and in vivo. First, the Src-specific tyrosine kinase inhibitor PP2 specifically blocks CagA
phosphorylation and cytoskeletal rearrangements thereby inhibiting the CagA-induced …
bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes
phosphorylated on tyrosine residues and initiates cytoskeletal rearrangements. We
demonstrate here that Src-like protein-tyrosine kinases mediate CagA phosphorylation in
vitro and in vivo. First, the Src-specific tyrosine kinase inhibitor PP2 specifically blocks CagA
phosphorylation and cytoskeletal rearrangements thereby inhibiting the CagA-induced …