Genetic susceptibility to herpes simplex virus 1 encephalitis in mice and humans
Current opinion in allergy and clinical immunology, 2007•journals.lww.com
Herpes simplex encephalitis results from a series of monogenic primary immunodeficiencies
that impair the TLR3 and UNC-93B-dependent production of IFNα/β and IFNλ in the central
nervous system, at least in a fraction of children. This is not only crucial for the
understanding of immunity to herpes simplex virus 1, but also for the diagnosis and
treatment of herpes simplex encephalitis.
that impair the TLR3 and UNC-93B-dependent production of IFNα/β and IFNλ in the central
nervous system, at least in a fraction of children. This is not only crucial for the
understanding of immunity to herpes simplex virus 1, but also for the diagnosis and
treatment of herpes simplex encephalitis.
Summary
Herpes simplex encephalitis results from a series of monogenic primary immunodeficiencies that impair the TLR3 and UNC-93B-dependent production of IFNα/β and IFNλ in the central nervous system, at least in a fraction of children. This is not only crucial for the understanding of immunity to herpes simplex virus 1, but also for the diagnosis and treatment of herpes simplex encephalitis.
Lippincott Williams & Wilkins