Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases
Y Rouillé, SJ Duguay, K Lund, M Furuta, Q Gong… - Frontiers in …, 1995 - Elsevier
The recent discovery of a novel family of precursor processing endoproteases has greatly
accelerated progress in understanding the complex mechanisms underlying the maturation
of prohormones, neuropeptides, and many other precursor-derived proteins. At least six
members of this family have been found thus far in mammalian species, several having
alternatively spliced isoforms, and related enzymes have been identified in many
invertebrates, including molluscs, insects, nematodes, and coelenterates. The proprotein …
accelerated progress in understanding the complex mechanisms underlying the maturation
of prohormones, neuropeptides, and many other precursor-derived proteins. At least six
members of this family have been found thus far in mammalian species, several having
alternatively spliced isoforms, and related enzymes have been identified in many
invertebrates, including molluscs, insects, nematodes, and coelenterates. The proprotein …