Induction of protective CTL responses in newborn mice by a murine retrovirus
M Sarzotti, DS Robbins, PM Hoffman - Science, 1996 - science.org
M Sarzotti, DS Robbins, PM Hoffman
Science, 1996•science.orgThe susceptibility of neonates to virus-induced disease is thought to reflect, in part, the
immaturity of their immune systems. However, inoculation of newborn mice with low doses of
Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL)
response. The inability of neonates to develop a CTL response to high doses of virus was
not the result of immunological immaturity but correlated with the induction of a
nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the …
immaturity of their immune systems. However, inoculation of newborn mice with low doses of
Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL)
response. The inability of neonates to develop a CTL response to high doses of virus was
not the result of immunological immaturity but correlated with the induction of a
nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the …
The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.
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