Interleukin-22: a novel T-and NK-cell derived cytokine that regulates the biology of tissue cells
K Wolk, R Sabat - Cytokine & growth factor reviews, 2006 - Elsevier
Interleukin (IL)-22, discovered in 2000, is a member of the IL-10 family of cytokines. The
major sources of IL-22 are activated T1-and NK-cells. IL-22 acts via a heterodimeric receptor
complex consisting of IL-22R1 and IL-10R2. Neither resting nor activated immune cells
express IL-22R1 or respond to IL-22. In contrast, tissue cells at outer body barriers, ie of the
skin, kidney, and the digestive and respiratory systems are targets of this cytokine. IL-22
functions by promoting the anti-microbial defense, protecting against damage, and re …
major sources of IL-22 are activated T1-and NK-cells. IL-22 acts via a heterodimeric receptor
complex consisting of IL-22R1 and IL-10R2. Neither resting nor activated immune cells
express IL-22R1 or respond to IL-22. In contrast, tissue cells at outer body barriers, ie of the
skin, kidney, and the digestive and respiratory systems are targets of this cytokine. IL-22
functions by promoting the anti-microbial defense, protecting against damage, and re …