Dissecting tumour pathophysiology using intravital microscopy
For a systemically administered therapeutic agent to reach neoplastic cells, it must enter the
blood circulation, cross the vessel wall, move through the extracellular matrix and avoid
getting cleared by the lymphatics. In tumours, each of these barriers is abnormal, changes
with space and time, and depends on host–tumour interactions. Intravital microscopy has
provided unprecedented molecular, cellular, anatomical and functional insights into these
barriers and has revealed new approaches to improved detection and treatment.
blood circulation, cross the vessel wall, move through the extracellular matrix and avoid
getting cleared by the lymphatics. In tumours, each of these barriers is abnormal, changes
with space and time, and depends on host–tumour interactions. Intravital microscopy has
provided unprecedented molecular, cellular, anatomical and functional insights into these
barriers and has revealed new approaches to improved detection and treatment.
Abstract
For a systemically administered therapeutic agent to reach neoplastic cells, it must enter the blood circulation, cross the vessel wall, move through the extracellular matrix and avoid getting cleared by the lymphatics. In tumours, each of these barriers is abnormal, changes with space and time, and depends on host–tumour interactions. Intravital microscopy has provided unprecedented molecular, cellular, anatomical and functional insights into these barriers and has revealed new approaches to improved detection and treatment.
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