Up-regulation of hepatic heme oxygenase-1 expression by locally induced interleukin-6 in rats administered carbon tetrachloride intraperitoneally
K Yamaji, Y Ochiai, K Ohnishi, A Yawata, T Chikuma… - Toxicology letters, 2008 - Elsevier
We previously reported that interleukin-6 (IL-6) was locally produced in the early period after
intraperitoneal (ip) or subcutaneous carbon tetrachloride (CCl4) administration, but not after
oral (po) administration. In the present study, we focused on the up-regulation of stress-
inducible proteins induced by IL-6 after ip CCl4 administration. The expression of heme
oxygenase-1 (HO-1)(EC 1.14. 99.3) mRNA and protein were induced more in rats
administered CCl4 via the ip route, compared with the po route; however, expression of heat …
intraperitoneal (ip) or subcutaneous carbon tetrachloride (CCl4) administration, but not after
oral (po) administration. In the present study, we focused on the up-regulation of stress-
inducible proteins induced by IL-6 after ip CCl4 administration. The expression of heme
oxygenase-1 (HO-1)(EC 1.14. 99.3) mRNA and protein were induced more in rats
administered CCl4 via the ip route, compared with the po route; however, expression of heat …
