[HTML][HTML] The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein
D Kalant, SA Cain, M Maslowska, AD Sniderman… - Journal of Biological …, 2003 - ASBMB
The orphan receptor C5L2 has recently been described as a high affinity binding protein for
complement fragments C5a and C3a that, unlike the previously described C5a receptor
(CD88), couples only weakly to G i-like G proteins (Cain, SA, and Monk, PN (2002) J. Biol.
Chem. 277, 7165–7169). Here we demonstrate that C5L2 binds the metabolites of C4a and
C3a, C4a des-Arg 77, and C3a des-Arg 77 (also known as the acylation-stimulating protein
or ASP) at a site distinct from the C5a binding site. The binding of these metabolites to C5L2 …
complement fragments C5a and C3a that, unlike the previously described C5a receptor
(CD88), couples only weakly to G i-like G proteins (Cain, SA, and Monk, PN (2002) J. Biol.
Chem. 277, 7165–7169). Here we demonstrate that C5L2 binds the metabolites of C4a and
C3a, C4a des-Arg 77, and C3a des-Arg 77 (also known as the acylation-stimulating protein
or ASP) at a site distinct from the C5a binding site. The binding of these metabolites to C5L2 …