CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C-dependent pathway
W Kasinrerk, N Tokrasinwit, S Moonsom, H Stockinger - Immunology letters, 2000 - Elsevier
CD99 is a 32 kDa cell surface glycoprotein which is involved in cell adhesion. Engagement
of the CD99 molecule by CD99 monoclonal antibodies has been shown to induce
homotypic aggregation of various cell types. By using a newly established CD99
monoclonal antibody, MT99/3, we show here that LFA-1/ICAM-1 independent cell adhesion
pathways are activated via CD99. Engagement of the CD99 molecule by MT99/3 induced
homotypic cell aggregation of Jurkat T-cells within 30 min reaching its maximal level within 4 …
of the CD99 molecule by CD99 monoclonal antibodies has been shown to induce
homotypic aggregation of various cell types. By using a newly established CD99
monoclonal antibody, MT99/3, we show here that LFA-1/ICAM-1 independent cell adhesion
pathways are activated via CD99. Engagement of the CD99 molecule by MT99/3 induced
homotypic cell aggregation of Jurkat T-cells within 30 min reaching its maximal level within 4 …