Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins
CW Wilkinson - Peptides, 2006 - Elsevier
Phylogenetic, developmental, anatomic, and stimulus-specific variations in post-translational
processing of POMC are well established. For melanocortins, the role of α-N-acetylation and
the selective activities of α, β, and γ forms are of special interest. Acetylation may shift the
predominant activity of POMC products between endorphinergic and melanocortinergic
actions—which are often in opposition. This review addresses:(1) variations in POMC
processing;(2) the influence of acetylation on the functional activity of α-MSH;(3) state-and …
processing of POMC are well established. For melanocortins, the role of α-N-acetylation and
the selective activities of α, β, and γ forms are of special interest. Acetylation may shift the
predominant activity of POMC products between endorphinergic and melanocortinergic
actions—which are often in opposition. This review addresses:(1) variations in POMC
processing;(2) the influence of acetylation on the functional activity of α-MSH;(3) state-and …