[HTML][HTML] Mxi1 is a repressor of the c-Myc promoter and reverses activation by USF
TC Lee, EB Ziff - Journal of Biological Chemistry, 1999 - ASBMB
The basic region/helix-loop-helix/leucine zipper (B-HLH-LZ) oncoprotein c-Myc is abundant
in proliferating cells and forms heterodimers with Max protein that bind to E-box sites in DNA
and stimulate genes required for proliferation. A second B-HLH-LZ protein, Mxi1, is induced
during terminal differentiation, and forms heterodimers with Max that also bind E-boxes but
tether the mSin3 transcriptional repressor protein along with histone deacetylase thereby
antagonizing Myc-dependent activation. We show that Mxi1 also antagonizes Myc by a …
in proliferating cells and forms heterodimers with Max protein that bind to E-box sites in DNA
and stimulate genes required for proliferation. A second B-HLH-LZ protein, Mxi1, is induced
during terminal differentiation, and forms heterodimers with Max that also bind E-boxes but
tether the mSin3 transcriptional repressor protein along with histone deacetylase thereby
antagonizing Myc-dependent activation. We show that Mxi1 also antagonizes Myc by a …