[HTML][HTML] PUMA, a novel proapoptotic gene, is induced by p53
K Nakano, KH Vousden - Molecular cell, 2001 - cell.com
K Nakano, KH Vousden
Molecular cell, 2001•cell.comThe p53 tumor-suppressor protein functions as a transcriptional activator, and several p53-
inducible genes that play a role in the induction of apoptosis in response to p53 have been
described. We have identified a novel gene named PUMA (p53 upregulated modulator of
apoptosis) as a target for activation by p53. This gene encodes two BH3 domain–containing
proteins (PUMA-α and PUMA-β) that are induced in cells following p53 activation. PUMA-α
and PUMA-β show similar activities; they bind to Bcl-2, localize to the mitochondria to induce …
inducible genes that play a role in the induction of apoptosis in response to p53 have been
described. We have identified a novel gene named PUMA (p53 upregulated modulator of
apoptosis) as a target for activation by p53. This gene encodes two BH3 domain–containing
proteins (PUMA-α and PUMA-β) that are induced in cells following p53 activation. PUMA-α
and PUMA-β show similar activities; they bind to Bcl-2, localize to the mitochondria to induce …
Abstract
The p53 tumor-suppressor protein functions as a transcriptional activator, and several p53-inducible genes that play a role in the induction of apoptosis in response to p53 have been described. We have identified a novel gene named PUMA (p53 upregulated modulator of apoptosis) as a target for activation by p53. This gene encodes two BH3 domain–containing proteins (PUMA-α and PUMA-β) that are induced in cells following p53 activation. PUMA-α and PUMA-β show similar activities; they bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1–dependent pathway.
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