[HTML][HTML] Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice
FU Muller, G Lewin, HA Baba, P Bokník… - Journal of Biological …, 2005 - ASBMB
The transcriptional activation mediated by cAMP-response element (CRE) and transcription
factors of the CRE-binding protein (CREB)/CRE modulator (CREM) family represents an
important mechanism of cAMP-dependent gene regulation possibly implicated in
detrimental effects of chronic β-adrenergic stimulation in end-stage heart failure. We studied
the cardiac role of CREM in transgenic mice with heart-directed expression of CREM-IbΔC-
X, a human cardiac CREM isoform. Transgenic mice displayed atrial enlargement with atrial …
factors of the CRE-binding protein (CREB)/CRE modulator (CREM) family represents an
important mechanism of cAMP-dependent gene regulation possibly implicated in
detrimental effects of chronic β-adrenergic stimulation in end-stage heart failure. We studied
the cardiac role of CREM in transgenic mice with heart-directed expression of CREM-IbΔC-
X, a human cardiac CREM isoform. Transgenic mice displayed atrial enlargement with atrial …