PI3-K and GSK-3: Akt-ing together with microtubules
GJ Buttrick, JG Wakefield - Cell cycle, 2008 - Taylor & Francis
GJ Buttrick, JG Wakefield
Cell cycle, 2008•Taylor & FrancisPhosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen
Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule
(MT) dynamics and organisation. Here we review the role of this signalling pathway in
controlling MTs, and explore ways in which the kinases and their substrates may co-operate
to spatially regulate MTs in different contexts.
Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule
(MT) dynamics and organisation. Here we review the role of this signalling pathway in
controlling MTs, and explore ways in which the kinases and their substrates may co-operate
to spatially regulate MTs in different contexts.
Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organisation. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the kinases and their substrates may co-operate to spatially regulate MTs in different contexts.
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