[HTML][HTML] Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells
E Camerer, H Kataoka, M Kahn, K Lease… - Journal of Biological …, 2002 - ASBMB
The coagulation protease Factor Xa (Xa) 1 triggers a variety of cellular responses that may
be important for inflammatory reactions to tissue injury. Protease-activated receptors (PAR1,
PAR2, and PAR4) can mediate Xa signaling in heterologous expression systems. However,
other candidate Xa receptors have been described, and the extent to which one or more
PARs account for Xa signaling in relevant differentiated cells is unknown. We examined Xa
signaling in endothelial cells from wild-type and PAR-deficient mice. Wild-type endothelial …
be important for inflammatory reactions to tissue injury. Protease-activated receptors (PAR1,
PAR2, and PAR4) can mediate Xa signaling in heterologous expression systems. However,
other candidate Xa receptors have been described, and the extent to which one or more
PARs account for Xa signaling in relevant differentiated cells is unknown. We examined Xa
signaling in endothelial cells from wild-type and PAR-deficient mice. Wild-type endothelial …