[HTML][HTML] Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics
Sphingosine 1-phosphate subtype 1 (S1P 1) receptor agonists alter lymphocyte trafficking
and endothelial barrier integrity in vivo. Among these is the potent, non-selective agonist,
FTY720-P, whose mechanism of action has been suggested to correlate with S1P 1 down-
regulation. Discovery of the in vivo active S1P 1-selective agonist, SEW2871, has
broadened our understanding of minimal requirements for S1P 1 function while highlighting
differences regarding agonist effect on S1P 1 fate, because SEW2871 does not degrade …
and endothelial barrier integrity in vivo. Among these is the potent, non-selective agonist,
FTY720-P, whose mechanism of action has been suggested to correlate with S1P 1 down-
regulation. Discovery of the in vivo active S1P 1-selective agonist, SEW2871, has
broadened our understanding of minimal requirements for S1P 1 function while highlighting
differences regarding agonist effect on S1P 1 fate, because SEW2871 does not degrade …