[HTML][HTML] The Inducible G Protein-coupled Receptor edg-1 Signals via the Gi/Mitogen-activated Protein Kinase Pathway (∗)
The edg-1 gene encodes an inducible G protein-coupled receptor (GPR) homologue that is
induced during the in vitro differentiation of human endothelial cells. The aim of this study
was to investigate the G protein-coupling and-signaling properties of the edg-1 polypeptide.
The third cytosolic loop (i 3) of edg-1 associates with Giα and G o α polypeptides in a
guanosine 5′-O-(thiotriphosphate)-sensitive manner. Immunoprecipitation of the edg-1
polypeptide in transfected cells results in the co-precipitation of Giα1 and Giα3 polypeptides …
induced during the in vitro differentiation of human endothelial cells. The aim of this study
was to investigate the G protein-coupling and-signaling properties of the edg-1 polypeptide.
The third cytosolic loop (i 3) of edg-1 associates with Giα and G o α polypeptides in a
guanosine 5′-O-(thiotriphosphate)-sensitive manner. Immunoprecipitation of the edg-1
polypeptide in transfected cells results in the co-precipitation of Giα1 and Giα3 polypeptides …