[HTML][HTML] Comprehensive mapping of poxvirus vCCI chemokine-binding protein: expanded range of ligand interactions and unusual dissociation kinetics
JM Burns, DJ Dairaghi, M Deitz, M Tsang… - Journal of Biological …, 2002 - ASBMB
In compiling a comprehensive map of the ligand binding capacity of elements within the
chemokine system, we have determined the spectrum of chemokines capable of interacting
with the poxvirus-encoded viral CC chemokine inhibitor, vCCI. More than 80 chemokines
were tested in parallel for their ability to displace radiolabeled signature chemokines from
vCCI. Of these chemokines, 26 showed potential high affinity interactions. These interactions
revealed an expanded spectrum of binding capacity for vCCI to now include molecules such …
chemokine system, we have determined the spectrum of chemokines capable of interacting
with the poxvirus-encoded viral CC chemokine inhibitor, vCCI. More than 80 chemokines
were tested in parallel for their ability to displace radiolabeled signature chemokines from
vCCI. Of these chemokines, 26 showed potential high affinity interactions. These interactions
revealed an expanded spectrum of binding capacity for vCCI to now include molecules such …