[HTML][HTML] Cisplatin and adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line
JT Drummond, A Anthoney, R Brown… - Journal of Biological …, 1996 - ASBMB
In contrast to parental A2780 ovarian tumor cells, extracts of one doxorubicin-resistant and
two independent cis-diamminedichloroplatinum (II)-resistant derivatives are defective in
strand-specific mismatch repair. The repair defect of the three hypermutable, drug-resistant
cell lines is only evident when the strand break that directs the reaction is located 3′ to the
mismatch, and in each case repair is restored to extracts by addition of purified MutLα
heterodimer. As judged by immunological assay, drug resistance is associated with the …
two independent cis-diamminedichloroplatinum (II)-resistant derivatives are defective in
strand-specific mismatch repair. The repair defect of the three hypermutable, drug-resistant
cell lines is only evident when the strand break that directs the reaction is located 3′ to the
mismatch, and in each case repair is restored to extracts by addition of purified MutLα
heterodimer. As judged by immunological assay, drug resistance is associated with the …