[PDF][PDF] Control of immune responses by savenger liver endothelial cells

PA Knolle, A Limmer - Swiss medical weekly, 2003 - smw.ch
PA Knolle, A Limmer
Swiss medical weekly, 2003smw.ch
MHC-restricted presentation of exogenous antigens for CD4 as well as CD8 T cells occurs
equally with high efficiency. Importantly, CD4 and CD8 T cells that engaged in cognate
interaction with LSEC have a tolerant phenotype. Thus LSEC contribute an important
immune function to the liver: control of the immune response against circulating soluble
antigens.
MHC-restricted presentation of exogenous antigens for CD4 as well as CD8 T cells occurs equally with high efficiency. Importantly, CD4 and CD8 T cells that engaged in cognate interaction with LSEC have a tolerant phenotype. Thus LSEC contribute an important immune function to the liver: control of the immune response against circulating soluble antigens.
smw.ch