[HTML][HTML] Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytesin vitro and in vivo
PCN Rensen, LAJM Sliedregt, M Ferns… - Journal of biological …, 2001 - ASBMB
The asialoglycoprotein receptor (ASGPr) on hepatocytes plays a role in the clearance of
desialylated proteins from the serum. Although its sugar preference (N-acetylgalactosamine
(GalNAc)≫ galactose) and the effects of ligand valency (tetraantennary> triantennary≫
diantennary≫ monoantennary) and sugar spacing (20 Å≫ 10 Å≫ 4 Å) are well
documented, the effect of particle size on recognition and uptake of ligands by the receptor
is poorly defined. In the present study, we assessed the maximum ligand size that still allows …
desialylated proteins from the serum. Although its sugar preference (N-acetylgalactosamine
(GalNAc)≫ galactose) and the effects of ligand valency (tetraantennary> triantennary≫
diantennary≫ monoantennary) and sugar spacing (20 Å≫ 10 Å≫ 4 Å) are well
documented, the effect of particle size on recognition and uptake of ligands by the receptor
is poorly defined. In the present study, we assessed the maximum ligand size that still allows …