The mechanism of naked DNA uptake and expression
JA Wolff, V Budker - Advances in genetics, 2005 - Elsevier
The administration of naked nucleic acids into animals is increasingly being used as a
research tool to elucidate mechanisms of gene expression and the role of genes and their
cognate proteins in the pathogenesis of disease in animal models (Herweijer and Wolff,
2003; Hodges and Scheule, 2003). It is also being used in several human clinical trials for
genetic vaccines, Duchenne muscular dystrophy, peripheral limb ischemia, and cardiac
ischemia (Davis et al., 1996; Romero et al., 2002; Tsurumi et al., 1997). Naked DNA is an …
research tool to elucidate mechanisms of gene expression and the role of genes and their
cognate proteins in the pathogenesis of disease in animal models (Herweijer and Wolff,
2003; Hodges and Scheule, 2003). It is also being used in several human clinical trials for
genetic vaccines, Duchenne muscular dystrophy, peripheral limb ischemia, and cardiac
ischemia (Davis et al., 1996; Romero et al., 2002; Tsurumi et al., 1997). Naked DNA is an …