Advancing paternal age and bipolar disorder

EM Frans, S Sandin, A Reichenberg… - Archives of general …, 2008 - jamanetwork.com
Context Advancing paternal age has been reported as a risk factor for neurodevelopmental
disorders. Objectives To determine whether advanced paternal age is associated with an
increased risk of BPD in the offspring and to assess if there was any difference in risk when
analyzing patients with early-onset BPD separately. Design A nationwide nested case-
control study based on Swedish registers was performed. Risk for BPD in the offspring of
older fathers was estimated using conditional logistic regression analysis controlling for …