[HTML][HTML] Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing …
JB de Haan, C Bladier, P Griffiths, M Kelner… - Journal of Biological …, 1998 - ASBMB
Glutathione peroxidases have been thought to function in cellular antioxidant defense.
However, some recent studies on Gpx1 knockout (−/−) mice have failed to show a role for
Gpx1 under conditions of oxidative stress such as hyperbaric oxygen and the exposure of
eye lenses to high levels of H 2 O 2. These findings have, unexpectedly, raised the issue of
the role of Gpx1, especially under conditions of oxidative stress. Here we demonstrate a role
for Gpx1 in protection against oxidative stress by showing that Gpx1 (−/−) mice are highly …
However, some recent studies on Gpx1 knockout (−/−) mice have failed to show a role for
Gpx1 under conditions of oxidative stress such as hyperbaric oxygen and the exposure of
eye lenses to high levels of H 2 O 2. These findings have, unexpectedly, raised the issue of
the role of Gpx1, especially under conditions of oxidative stress. Here we demonstrate a role
for Gpx1 in protection against oxidative stress by showing that Gpx1 (−/−) mice are highly …