Involvement of hyaluronan in epidermal Langerhans cell maturation and migration in vivo
DI Mummert, A Takashima, L Ellinger… - Journal of dermatological …, 2003 - Elsevier
Background: Langerhans cells (LC) normally reside in the epidermis, where they constantly
monitor the integrity of this microenvironment. Skin exposure to reactive haptens or other pro-
inflammatory stimuli triggers LC migration to the draining lymph nodes, where they function
as potent antigen presenting cells. At the same time, migratory LC exhibit features of mature
dendritic cells. Objective: The purpose of this study was to determine the potential role (s) of
hyaluronan (HA) in the process of LC maturation. Methods: Using a recently described …
monitor the integrity of this microenvironment. Skin exposure to reactive haptens or other pro-
inflammatory stimuli triggers LC migration to the draining lymph nodes, where they function
as potent antigen presenting cells. At the same time, migratory LC exhibit features of mature
dendritic cells. Objective: The purpose of this study was to determine the potential role (s) of
hyaluronan (HA) in the process of LC maturation. Methods: Using a recently described …