[HTML][HTML] Atrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium
H Chen, YC Levine, DE Golan, T Michel… - Journal of biological …, 2008 - ASBMB
Nitric oxide (NO)-and atrial natriuretic peptide (ANP)-initiated cGMP signaling cascades are
important in the maintenance of cardiovascular homeostasis. The molecular signaling
mechanisms downstream of cGMP are not well understood, however. We have used small
interfering RNA (siRNA) approaches to specifically knock down a series of signaling
proteins in bovine aortic endothelial cells, and we have combined biochemical analyses
with physiological assays to investigate cGMP-mediated signal transduction pathways …
important in the maintenance of cardiovascular homeostasis. The molecular signaling
mechanisms downstream of cGMP are not well understood, however. We have used small
interfering RNA (siRNA) approaches to specifically knock down a series of signaling
proteins in bovine aortic endothelial cells, and we have combined biochemical analyses
with physiological assays to investigate cGMP-mediated signal transduction pathways …