[HTML][HTML] Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells
J Hood, HJ Granger - Journal of Biological Chemistry, 1998 - ASBMB
Vascular endothelial growth factor (VEGF) is an endothelium-specific, secreted protein that
acts as a vasodilator, angiogenic peptide, and hyperpermeability factor. Recent reports have
shown that nitric oxide synthase inhibitors block proliferation and microvascular
hyperpermeability induced by VEGF. This study examined the mechanisms by which nitric
oxide and its downstream signals mediate the VEGF-induced proliferative response in
human umbilical vein endothelial cells (HUVECs). Nitric oxide synthase blockade byN ω …
acts as a vasodilator, angiogenic peptide, and hyperpermeability factor. Recent reports have
shown that nitric oxide synthase inhibitors block proliferation and microvascular
hyperpermeability induced by VEGF. This study examined the mechanisms by which nitric
oxide and its downstream signals mediate the VEGF-induced proliferative response in
human umbilical vein endothelial cells (HUVECs). Nitric oxide synthase blockade byN ω …