[HTML][HTML] Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I
A Smolenski, W Poller, U Walter… - Journal of Biological …, 2000 - ASBMB
cGMP-dependent protein kinase type I (cGK I), a major constituent of the atrial natriuretic
peptide (ANP)/nitric oxide/cGMP signal transduction pathway, phosphorylates the
vasodilator-stimulated phosphoprotein (VASP), a member of the Ena/VASP family of
proteins involved in regulation of the actin cytoskeleton. Here we demonstrate that
stimulation of human umbilical vein endothelial cells (HUVECs) by both ANP and 8-(4-
chlorophenylthio) guanosine 3′: 5′-monophosphate (8-pCPT-cGMP) activates transfected …
peptide (ANP)/nitric oxide/cGMP signal transduction pathway, phosphorylates the
vasodilator-stimulated phosphoprotein (VASP), a member of the Ena/VASP family of
proteins involved in regulation of the actin cytoskeleton. Here we demonstrate that
stimulation of human umbilical vein endothelial cells (HUVECs) by both ANP and 8-(4-
chlorophenylthio) guanosine 3′: 5′-monophosphate (8-pCPT-cGMP) activates transfected …