[CITATION][C] cdr2‐specific CTLs are detected in the blood of all patients with paraneoplastic cerebellar degeneration analyzed

RB Darnell, ML Albert - Annals of Neurology: Official Journal of …, 2000 - Wiley Online Library
Annals of Neurology: Official Journal of the American Neurological …, 2000Wiley Online Library
Evaluating whether persons are unable to walk and talk simultaneously (“stops walking
when talking”; SWWT) is a simple test with good predictive value for falls in frail,
institutionalized elderly persons. 1 Because it is relevant to know whether this test has
similar predictive value in other populations prone to falls, we studied SWWT in Parkinson's
disease (PD). Recurrent falls in PD are incapacitating, but their prediction is difficult. 2
Theoretically, SWWT should be sensitive in PD patients who have difficulty performing …
Evaluating whether persons are unable to walk and talk simultaneously (“stops walking when talking”; SWWT) is a simple test with good predictive value for falls in frail, institutionalized elderly persons. 1 Because it is relevant to know whether this test has similar predictive value in other populations prone to falls, we studied SWWT in Parkinson’s disease (PD). Recurrent falls in PD are incapacitating, but their prediction is difficult. 2 Theoretically, SWWT should be sensitive in PD patients who have difficulty performing multiple tasks sequentially or simultaneously. 3 This is also true when walking is one of the tasks. 4
Thirty-eight patients with idiopathic PD (mean age, 60.1 10.8 [SD] years; 34% women; mean Hoehn and Yahr stage, 2.3 0.7 [SD]) and 35 controls (mean age, 58.0 8.9 [SD] years; 74% women) participated. All persons were ambulant community residents without depression or cognitive impairment (MMSE 24). SWWT consisted of a conversation during a standardized 150-meter walk (positive result if persons stopped walking for 3 seconds). Because we wanted the conversation to be cognitively challenging, the investigator (YAMG) consistently used open (rather than closed) questions regarding details of the medical history and recent changes in medication. Such items are also emotionally important for most persons. Persons were followed up prospectively for 6 months, using standardized scoring forms to document all falls. Persons were also contacted by telephone every 2 weeks to ensure that all falls were documented. Recurrent (two or more) or injurious fallers were used as outcome measure. Fourteen of the PD patients (36.8%) reported 119 falls. Five of the controls (14.3%) reported a total of 7 falls. SWWT was abnormal in only 4 patients and in none of the controls. The reverse (stops talking while walking) never occurred. SWWT was positive in 2 patients that were fallers and in 2 patients who did not fall. Comparing fallers with nonfallers within the PD group, SWWT had a poor sensitivity (14.3%; 2/14), although the specificity was adequate (91.7%; 22/24). Pooling patients and controls improved the specificity (96.3%; 52/54) at the expense of the sensitivity (10.5%; 2/19).
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