Protective role of endothelial nitric oxide synthase
EWJA Albrecht, CA Stegeman… - The Journal of …, 2003 - Wiley Online Library
EWJA Albrecht, CA Stegeman, P Heeringa, RH Henning, H van Goor
The Journal of Pathology: A Journal of the Pathological Society of …, 2003•Wiley Online LibraryNitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to
anti‐proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the
nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS
(iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is
necessary for a good endothelial function and integrity. Endothelial derived NO is often seen
as a protective agent in a variety of diseases. This review will focus on the potential …
anti‐proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the
nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS
(iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is
necessary for a good endothelial function and integrity. Endothelial derived NO is often seen
as a protective agent in a variety of diseases. This review will focus on the potential …
Abstract
Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti‐proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases.
This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed. Copyright © 2002 John Wiley & Sons, Ltd.
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