[HTML][HTML] Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation
AL Eisen-Vandervelde, SN Waggoner, ZQ Yao… - Journal of Biological …, 2004 - ASBMB
Hepatitis C virus (HCV) is remarkably efficient at establishing persistent infection, suggesting
that it has evolved one or more strategies aimed at evading the host immune response. T
cell responses, including interferon-γ production, are severely suppressed in chronic HCV
patients. The HCV core protein has been previously shown to circulate in the bloodstream of
HCV-infected patients and inhibit host immunity through an interaction with gC1qR. To
determine the role of the HCV core-gC1qR interaction in modulation of inflammatory …
that it has evolved one or more strategies aimed at evading the host immune response. T
cell responses, including interferon-γ production, are severely suppressed in chronic HCV
patients. The HCV core protein has been previously shown to circulate in the bloodstream of
HCV-infected patients and inhibit host immunity through an interaction with gC1qR. To
determine the role of the HCV core-gC1qR interaction in modulation of inflammatory …