Direct interaction between emerin and lamin A
L Clements, S Manilal, DR Love, GE Morris - Biochemical and biophysical …, 2000 - Elsevier
L Clements, S Manilal, DR Love, GE Morris
Biochemical and biophysical research communications, 2000•ElsevierEmerin is the protein of the inner nuclear membrane that is affected by mutation in X-linked
Emery-Dreifuss muscular dystrophy. The autosomal dominant form of the disease is caused
by mutations in the lamin A/C gene. Several lines of circumstantial evidence have suggested
an interaction of emerin with lamins in the nuclear lamina but direct interaction between the
two proteins has not yet been demonstrated. We now demonstrate direct interaction
between recombinant emerin and lamin A molecules using biomolecular interaction …
Emery-Dreifuss muscular dystrophy. The autosomal dominant form of the disease is caused
by mutations in the lamin A/C gene. Several lines of circumstantial evidence have suggested
an interaction of emerin with lamins in the nuclear lamina but direct interaction between the
two proteins has not yet been demonstrated. We now demonstrate direct interaction
between recombinant emerin and lamin A molecules using biomolecular interaction …
Emerin is the protein of the inner nuclear membrane that is affected by mutation in X-linked Emery-Dreifuss muscular dystrophy. The autosomal dominant form of the disease is caused by mutations in the lamin A/C gene. Several lines of circumstantial evidence have suggested an interaction of emerin with lamins in the nuclear lamina but direct interaction between the two proteins has not yet been demonstrated. We now demonstrate direct interaction between recombinant emerin and lamin A molecules using biomolecular interaction analysis (BIA) and monoclonal antibodies. An emerin–lamin A interaction system may be related in function to the LAP2-lamin B system at the inner nuclear rim.
Elsevier