Solubility properties and specific assembly pathways of the B-type lamin from Caenorhabditis elegans

N Foeger, N Wiesel, D Lotsch, N Mücke… - Journal of structural …, 2006 - Elsevier
Lamins are nucleus-specific intermediate filament (IF) proteins that together with a complex
set of membrane proteins form a filamentous meshwork tightly adhering to the inner nuclear
membrane and being associated with the nuclear pore complexes. This so-called nuclear
lamina provides mechanical stability and, in addition, has been implicated in the spatial
organization of the heterochromatin. While increasing knowledge on the biological function
of lamins has been obtained in recent years, the assembly mechanism of lamin filaments at …