Intermediate filament dynamics

JE Eriksson, P Opal, RD Goldman - Current Opinion in Cell Biology, 1992 - Elsevier
Current Opinion in Cell Biology, 1992Elsevier
The view of intermediate filaments as static cytoskeletal elements is changing. Studies of
exogenous intermediate filament proteins, either microinjected or expressed from
transfected genes, have demonstrated that a continuous incorporation of subunits into the
polymerized filaments is taking place. This incorporation appears to be required for
maintaining normal cytoplasmic networks of intermediate filaments. At the post-translational
level, phosphorylation is an important factor in regulating dynamic aspects of intermediate …
Abstract
The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place. This incorporation appears to be required for maintaining normal cytoplasmic networks of intermediate filaments. At the post-translational level, phosphorylation is an important factor in regulating dynamic aspects of intermediate filament organization and structure.
Elsevier