p62 is involved in the mechanism of Mallory body formation
L Nan, Y Wu, F Bardag-Gorce, J Li, BA French… - … and molecular pathology, 2004 - Elsevier
p62 is a scaffolding protein that binds to polyubiquitin. It is involved in the degradation of
proteins by the proteasome. To determine if p62 is critical in the development of Mallory
bodies (MBs), primary culture hepatocytes from drug-primed mice were studied and the
results were compared with normal hepatocytes. Gene-specific gripNA (gp62) was added to
the medium of the primary cultures of the hepatocytes to inhibit the expression of p62.
Overexpression of p62 was achieved by transfecting the hepatocytes with a plasmid …
proteins by the proteasome. To determine if p62 is critical in the development of Mallory
bodies (MBs), primary culture hepatocytes from drug-primed mice were studied and the
results were compared with normal hepatocytes. Gene-specific gripNA (gp62) was added to
the medium of the primary cultures of the hepatocytes to inhibit the expression of p62.
Overexpression of p62 was achieved by transfecting the hepatocytes with a plasmid …