Keratins let liver live: mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies
NO Ku, P Strnad, BH Zhong, GZ Tao, BM Omary - Hepatology, 2007 - journals.lww.com
Abstract Keratin polypeptides 8 and 18 (K8/K18) are the cytoskeletal intermediate filament
proteins of hepatocytes while K8/K18/K19 are the keratins of hepatobiliary ductal cells.
Hepatocyte K8/K18 are highly abundant and behave as stress proteins with injury-inducible
expression. Human association studies show that K8/K18 germline heterozygous mutations
predispose to end-stage liver disease of multiple etiologies (≈ 3 fold increased risk), and to
liver disease progression in patients with chronic hepatitis C infection. These findings are …
proteins of hepatocytes while K8/K18/K19 are the keratins of hepatobiliary ductal cells.
Hepatocyte K8/K18 are highly abundant and behave as stress proteins with injury-inducible
expression. Human association studies show that K8/K18 germline heterozygous mutations
predispose to end-stage liver disease of multiple etiologies (≈ 3 fold increased risk), and to
liver disease progression in patients with chronic hepatitis C infection. These findings are …