[HTML][HTML] Proteomic analysis of astrocytic secretion in the mouse: Comparison with the cerebrospinal fluid proteome
M Lafon-Cazal, O Adjali, N Galéotti, J Poncet… - Journal of Biological …, 2003 - ASBMB
Astrocytes, the most abundant cell type in the central nervous system, are intimately
associated with synapses. They play a pivotal role in neuronal survival and the brain
inflammatory response. Some astrocytic functions are mediated by the secretion of
polypeptides. Using a proteomic approach, we have identified more than 30 proteins
released by cultured astrocytes. These include proteases and protease inhibitors, carrier
proteins, and antioxidant proteins. Exposing astrocytes to brefeldin A, which selectively …
associated with synapses. They play a pivotal role in neuronal survival and the brain
inflammatory response. Some astrocytic functions are mediated by the secretion of
polypeptides. Using a proteomic approach, we have identified more than 30 proteins
released by cultured astrocytes. These include proteases and protease inhibitors, carrier
proteins, and antioxidant proteins. Exposing astrocytes to brefeldin A, which selectively …